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Main articles published in academic journals

[ Toxicology, Physiology, and Pharmacology ]

Papers written in English

  • Kaji N, Nakayama S, Horiguchi K, Iino S, Ozaki H, Hori M. Disruption of the pacemaker activity of interstitial cells of Cajal via nitric oxide contributes to postoperative ileus. Neurogastroenterol. Motil. 2018. in Press.
  • Hirano T, Kaneda T, Ozaki H, Hori M. Angiotensin II, a unique vasoactive agent dissociates myosin light chain phosphorylation from contraction. J Vet Med Sci. 80:219-224, 2018.
  • Hori M, Yazama F, Matsuura Y, Yoshimoto R, Kaneda T, Yasumoto T, Ozaki H, Karaki H. Inhibition of actin polymerization by marine toxin pectenotoxin-2. J Vet Med Sci. 80:225-234, 2018.
  • Tsukamoto A, Ohgoda M, Haruki N, Hori M, Inomata T. The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis. J Vet Med Sci. 80(3):492-498, 2018.
  • Islam MS, Kaji N, Mikawa S, Yang Q, Kusakabe M, Hori M, Ozaki H. Induction of myosin light chain kinase and CPI-17 by TGF-β accelerates contractile activity in intestinal epithelial cells. J Vet Med Sci. 80(6):977-984, 2018.
  • Mikawa S, Kondo M, Kaji N, Mihara T, Yoshitake R, Nakagawa T, Takamoto M, Nishimura R, Shimada S, Ozaki H, Hori, M. Serotonin 3 receptor signaling regulates 5-fluorourachil-mediated apoptosis indirectly via TNF-α production by enhancing serotonin release from enterochromaffin cells. FASEB J 33(2):1669-1680, 2018.
  • Takuro Arimura, Antoine MUCHIR, Masayoshi Kuwahara, Sachio Morimoto, Taisuke ISHIKAWA, Cheng-Kun Du, Dong-Yun Zhan, Shu NAKAO, Noboru MACHIDA, Ryo TANAKA, Yoshihisa YAMANE, Takeharu HAYASHI, and Akinori Kimura. Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance. American Journal of Physiology Heart and Circulatory Physiology 2018. in Press.
  • Mai Tsunoda, Kazunari Miyamichi, Ryo Eguchi, Yasuo Sakuma, Yoshihiro Yoshihara, Takefumi Kikusui, Masayoshi Kuwahara, and Kazushige Touhara. Identification of an intra- and inter-specific tear protein signal in rodents. Current Biology. in Press.
  • Qunhui Yang, Wataru Fujii, Noriyuki Kaji, Shigeru Kakuta, Kodai Kada, Masayoshi Kuwahara, Hirokazu Tsubone, Hiroshi Ozaki, and Masatoshi Hori. The essential role of phospho-T38 CPI-17 in the maintenance of physiological blood pressure using genetically modified mice. FASEB J. 32: 2095–2109, 2018.
  • Kosuke Yasuda, Yu Hayashi, Takamasa Yoshida, Mitsuaki Kashiwagi, Nao Nakagawa, Takayuki Michikawa, Mika Tanaka, Reiko Ando, Arthur Huang, Toshihiko Hosoya, Thomas J. McHugh, Masayoshi Kuwahara, and Shigeyoshi Itohara. Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults. Translational Psychiatry 7: e1047, 2017.
  • Huang C-H, Wang C-C, Lind Y-J, Hori M, Jan T-R. Oral administration with diosgenin enhances the induction of intestinal T helper 1-like regulatory T cells in a murine model of food allergy. Int Immunopharmacol 42:59-66, 2017.
  • Morishita H, Noda T, Mochizuki N, Kaji N, Hori M, Kajioka S, Nakayama S. Micro-coordination of pacemaker potentials in the intestine of the mouse. Gastroenterology (in Motion section) 152:1831-1833, 2017.
  • Tsukamoto A, Sugimoto T, Onuki Y, Shinoda H, Mihara T, Hori M, Inomata T. The 5-HT3 receptor antagonist ondansetron attenuates pancreatic injury in cerulein-induced acute pancreatitis model. Inflammation 40(4):1409–1415, 2017.
  • Ruennarong N, Wongpanit K, Sakulthaew C, Giorgi M, Kumagai S, Poapolathep A, Poapolathep S. Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thai swamp buffaloes. J Vet Med Sci. 78(3):397-403, 2016.
  • Sinphithakkul P, Klangkaew N, Sanyathitiseree P, Giorgi M, Kumagai S, Poapolathep A, Poapolathep S. Pharmacokinetics of amoxicillin trihydrate in male Asian elephants (Elephas maximus) following intramuscular administration. J Vet Pharmacol Ther. 39(3):287-91, 2016.
  • Suknikom P, Jermnak U, Poapolathep S, Isariyodom S, Giorgi M, Kumagai S, Poapolathep A. Dispositions and tissue depletion of melamine in ducks. J Vet Pharmacol Ther. 39(1):90-4, 2016.
  • *Sato I, Sasaki J, Satoh H, Murata T, Otani K, Okada K. Radioactive cesium and potassium in cattle living in the ‘zone in preparation for the lifting of the evacuation order’ of the Fukushima nuclear accident. Anim Sci J. 88:1021-1026, 2016.
  • Alam M.S. and Kurohmaru M. Butylbenzyl phthalate induces spermatogenic cell apoptosis in prepubertal rats. Tissue and Cell 48:35-42, 2016.
  • Islam M.S, Horiguchi K, Iino S, Kaji N, Mikawa S, Hori M, Ozaki H. Epidermal growth factor is a critical regulator of the cytokine IL-33 in intestinal epithelial cells. Br J Pharmacol 173:2532-2542, 2016.
  • Kaji N, Horiguchi K, Iino S, Nakayama S, Ohwada T, Otani Y, Firman, Murata T, Sanders KM, Ozaki H, Hori M. Nitric oxide-induced oxidative stress impairs pacemaker function of murine interstitial cells of Cajal during inflammation. Pharmacol Res. 111:838-848, 2016.
  • Maehara T, Matsumoto K, Horiguchi K, Kondo M, Iino S, Horie S, Murata T, Tsubone H, Shimada S, Ozaki H, Hori M. Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus. Br J Pharmacol 172:1136-1147, 2015.
  • Amano S, Tsubone H, Hanafusa M, Yamasaki T, Nishizaka S, Yanagisawa H. Physical and physiological effectiveness of an overall health care program for middle-aged Japanese women with mild obesity: A pilot study. J Tradition. Complement. Med. 5:88-95, 2015.
  • Islam MS, Kusakabe M, Horiguchi K, Iino S, Nakamura T, Iwanaga K, Hashimoto H, Matsumoto S, Murata T, Hori M, Ozaki H. TGF-β promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice. Br J Pharmacol 171:375-388, 2014.
  • Tajima T, Murata T, Aritake K, Urade Y, Michishita M, Matsuoka, T, Narumiya S, Ozaki H, Hori M. EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals. Am J Physiolol (Gastrointest Liver Physiol) 302:G524-534, 2012.
  • Ando K, Takagi K, Tsubone H. Enhanced gastric retention of solid resin beads as a marker for emetic potential of agents in rats. J Toxicol Sci. 37(3):549-553,　2012.
  • Makimura Y, Ito K, Kuwahara M, Tsubone H. Augmented Activity of the Pelvic Nerve Afferent Mediated by TRP Channels in Dextran Sulfate Sodium (DSS)-Induced Colitis of Rats. J Vet Med Sci. 74(8), 2012.
  • Koichi Ito, Matevž A, Tomohiro Kawaguchi, Takefumi Kikusui, Masayoshi Kuwahara, and Hirokazu Tsubone. Intracerebroventricular administration of taurine impairs learning and memory in rats. Nutritional Neuroscience 15(2):70-77, 2012.
  • Hideo Ozawa, Shugo Watabe, and Yoshihiro Ochiai. Thermostability of striated and smooth adductor muscle tropomyosin from Yesso scallop Mizuhopecten yessoensis. J Biochem 147(6): 823-832, 2010.
  • Alam, M. S., Andriana, B. B., Tay, T. W., Tsunekawa, N.,Kanai, Y. and Kurohmaru, M. Single administration of di(n-butyl) phthalate delays spermatogenesis in prepubertal rats. Tissue & Cell 42(2):129-135, 2010.
  • Alam, M. S., Ohsako, S., Tay, T. W., Tsunekawa, N., Kanai, Y. and Kurohmaru, M. Di(n-butyl) phthalate induces vimentin filaments disruption in rat Sertoli cells:A possible relation with spermatogenic cell apoptosis. Anat Histol Embryol 39(3):186-193, 2010.
  • Zhu, X.B., Alam, M. S., Andriana, B. B., Tay, T. W., Choi, E. K., Tsunekawa, N., Kanai, Y. and Kurohmaru, M. Effects of Di-iso-butyl phthalate on testes of prepubertal rats and mice. Okajimas Folia Anat Jpn 86(4):129-136, 2010.
  • Alam, M. S., Ohsako, S., Matsuwaki, T., Zhu, X. B., Tsunekawa, N. Kanai, Y., Sone, H., Tohyama, C. and Kurohmaru, M. Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : a possible estrogenic effect of di(n-butyl) phthalate. Reproduction 139:427-437, 2010.
  • Islam MS, Yoshida H, Matsuki N, Ono K, Nagasaka R, Ushio H, Guo Y, Hiramatsu T, Hosoya T, Murata T, Hori M, Ozaki HAntioxidant, free radical scavenging and NF-κB inhibitory activities of phytosteryl ferulates: Structure-activity studies. J Pharmacol Sci 111:328-37, 2009.
  • Kuwahara M, Kawaguchi T, Ito K, Tsubone H. Effects of taurine on cardiovascular and autonomic nervous functions in cold exposed rats. Adv Exp Med Biol 643:533-540, 2009.
  • Ito K, Arko M, Kawaguchi T, Kuwahara M, and Tsubone H The effect of subacute supplementation of taurine on spatial learning and memory. Exp Anim 58(2):175-180, 2009.
  • Nakajima, K., Wu, G., Takeyama, N., Sugiura, K., Onodera, T. Insulinoma-associated protein-2-deficient mice develop sever forms of diabets induced by multiple low doses of streptozotocin. Int J Mol Med 24:23-27, 2009.
  • Uchino M, Ito K, Kuwahara M, Ebukuro S, Tsubone H. Interactions of carotid sinus or aortic input with emetic signals from gastric afferents and vestibular system. Auton Neurosci 144(1-2):36-42, 2008.
  • H. Sakamoto, Y. Kogo, J. Ohgane, N. Hattori, S. Yagi, S. Tanaka, K. Shiota Sequential changes in genome-wide DNA methylation status during adipocyte differentiation.
    Biochem Biophys Res Commun 366:360-366, 2008.
  • C. Maeda, S. Sato, N. Hattori, S. Tanaka, S. Yagi and K. Shiota. DNA hypomethylation circuit of the oocyte-specific histone H1foo gene in female germ cell lineage. Biol Reprod 78(5):816-821, 2008.
  • Akita M, Kuwahara M, Itoh F, Nakano Y, Osakabe N, Kurosawa T and Tsubone H Effects of cacao liquor polyphenols on cardiovascular and autonomic nervous functions in hypercholesterolemic rabbits. Bas Clin Pharmacol Toxicol 103:581-587, 2008.
  • Chida D, Hashimoto O, Kuwahara M, Sagara H, Osaka T, Tsubone H, Iwakura Y Increased fat: carbohydrate oxidation ratio in Il1ra (-/-) mice on a high-fat diet is associated with increased sympathetic tone. Diabetologia 51(9):1698-1706, 2008.
  • Wu, T., Jin, Y.X., Kato, H. and Fu, Z.W. Light and food signals cooperate to entrain the rat pineal circadian system. J Neurosci Res 86:3246-3255, 2008.

Papers written in Japanese

  • Hirokazu Tsubone
    Chapter 8: Safety assessment by utilizing general health effect index: Deployment of food safety science – For forecasting and controlling food risks (compiled by Research Center for Food Safety, The University of Tokyo)
    CMC Publishing, Tokyo, pp. 67-72, 2010
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